HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-(2-(4-(1-Methylethyl)-2-thiazolyl)ethenyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2-Methyl-4-(1-methylethyl)thiazole | HCID 520569 | — |
| Product | 3-(2-(4-(1-Methylethyl)-2-thiazolyl)ethenyl)benzaldehyde | HCID 54013853 | — |
Reaction Steps
4-(1-Methylethyl)-2-methylthiazole (546 mg, EP 0219436 p. 19) and isophthaladehyde (570 mg, 1.1 equiv.) are heated at reflux in acetic anhydride (1.1 mL, 3 equiv.) 16 hours. The reaction mixture is cooled and the acetic acid and anhydride are co-evaporated with toluene. The title compound is purified by flash chromatography on silica using EtOAc:hexane 10:90.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04962117 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-c88d99a0ca7245358ebb6512e838011e |
| Source note | uspto-grants-1990_10 |