2-(6-methoxynaphthalen-2-yl)prop-2-enoic Acid → Naproxen

Participants

Reaction Steps

In a 100 ml autoclave, the inside atmosphere of which had previously been replaced with argon, were placed 0.45 g (2 mmoles) of 6-methoxy-α-methylene-2-naphthaleneacetic acid and 20 ml of methanol. Then, 3.6 mg (0.004 mmole) of Ru2C14((-)-T-BINAP)2 (NEt3) prepared in Referential Example 1 was added to the mixture to perform hydrogenation for 24 hours at a hydrogen pressure of 40 kg/cm2 and at a reaction temperature of 20° C. Thereafter, the solvent was distilled off to provide 0.42 g of naproxen. The yield was 92%.

Provenance & Evidence