2-(6-methoxynaphthalen-2-yl)prop-2-enoic Acid → Naproxen

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In a 100 ml autoclave, the inside atmosphere of which had previously been replaced with argon, were placed 0.45 g (2 mmoles) of 6-methoxy-α-methylene-2-naphthaleneacetic acid and 20 ml of methanol. Then, 2.0 mg (0.002 mmole) of Ru((-)-T-BINAP)(O2CCF3)2 prepared in Referential Example 4 was added to the mixture to perform hydrogenation for 24 hours at a hydrogen pressure of 40 kg/cm2 and at a reaction temperature of 20° C. Thereafter, the solvent was distilled off to provide 0.43 g of naproxen. The yield thereof was 93.7%.

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