反应详情

In a 100 ml autoclave, the inside atmosphere of which had previously been replaced with argon, were placed 0.36 g (2 mmoles) of p-methoxyatropic acid and 20 ml of methanol. Then, 7.5 mg (0.009 mmole) of Ru((+)-BINAP)-(O2CCH3)2 prepared according to the same manner as in Referential Example 3 except using (+)-BINAP in place of (-)-BINAP was added to the mixture to perform hydrogenation for 12 hours at a hydrogen pressure of 100 kg/cm2 and at a reaction temperature of 19° C. Thereafter, the solvent was distilled off to provide 0.32 g of (2R)-(-)-2-(p-methoxyphenyl)propionic acid. The yield was 89%.

1. additionwas added to the mixture
2. customfor 12 hours
3. customat a reaction temperature of 19° C
4. distillationThereafter, the solvent was distilled off