Sodium Carbonate → 2,4-Difluoro-1-(trifluoromethyl)benzene

Participants

Reaction Steps

100 g of 3-chloro-2,4-difluorobenzotrifluoride in 500 ml of acetonitrile and 60 g of pulverulent sodium carbonate were initially introduced into a hydrogenation apparatus equipped with a diffuser stone and a stirrer. 10 g of catalyst (5% by weight of metallic palladium on activated charcoal) were then added, and hydrogen was passed in at 80° C. for 10 hours Subsequently, the batch was cooled and filtered, and the filtrate was distilled via a column packed with perforated rins made of stainless steel. 56 g of 2,4-difluorobenzotrifluoride having a boiling point of 105° to 106° C. at 1,030 mbar were obtained. The refractive index nD20 was 1.3968.

Provenance & Evidence