HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Benzyloxy-3-hexadecyloxypropyl 1,1-dimethyl-1,2,3,4-tetrahydroquinolinio-2-ylmethyl phosphate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2-(Benzyloxy)-3-(hexadecyloxy)propan-1-ol | HCID 13277140 | — |
| Reactant | 1,1-Dimethyl-1,2,3,4-tetrahydro-2-hydroxymethylquinolinium p-toluenesulfonate | HCID 15052241 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-Benzyloxy-3-hexadecyloxypropyl 1,1-dimethyl-1,2,3,4-tetrahydroquinolinio-2-ylmethyl phosphate | HCID 131716658 | — |
Reaction Steps
The procedures of Example 7 were repeated using 406 mg of 2-benzyloxy-3-hexadecyloxy-1-propanol, 580 mg of 1,1-dimethyl-1,2,3,4-tetrahydro-2-hydroxymethylquinolinium p-toluenesulfonate prepared in Reference Example 11, 0.1 ml of phosphorus oxychloride, 0.3 ml of triethylamine, 3 ml of chloroform having passed through an alumina column, and 8 ml of dry pyridine, to give 150 mg of the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04962096 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-a8f4cde856f74174b0eb0c25705bc817 |
| Source note | uspto-grants-1990_10 |