Heptane → HCID 15616169, compound

HRID 1088584Notes

Reaction equation

HRID 1088584 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH3:9])[CH:5]=[C:4]([O:10][CH3:11])[N:3]=1.[N:12]([S:15]([O:18][C:19]1[CH:30]=[CH:29][CH:28]=[CH:27][C:20]=1[C:21]([O:23][CH2:24][CH2:25][Cl:26])=[O:22])(=[O:17])=[O:16])=[C:13]=[O:14].CCCCCCC>ClCCl>[CH3:9][O:8][C:6]1[CH:5]=[C:4]([O:10][CH3:11])[N:3]=[C:2]([NH:1][C:13](=[O:14])[NH:12][S:15]([O:18][C:19]2[CH:30]=[CH:29][CH:28]=[CH:27][C:20]=2[C:21]([O:23][CH2:24][CH2:25][Cl:26])=[O:22])(=[O:16])=[O:17])[N:7]=1

Participants

5

Reactant 3

HCID 8900HeptaneHCID 1189462-Amino-4,6-dimethoxypyrimidineHCID 14480893HCID 14480893, compound

Product 1

HCID 15616169HCID 15616169, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

2.02 g (0.013 mole) of 2-amino-4,6-dimethoxypyrimidine are dissolved in 80 ml of dichloromethane, and 4.28 g (0.014 mole) of 2-chloroethyl 2-isocyanatosulfonyloxybenzoate, dissolved in 20 ml of dichloromethane, are added at 0° C. The reaction mixture is stirred at room temperature for 18 hours and is then stirred into 600 ml of n-heptane. In this manner, 4.72 g (79% of theory) of 2-chloroethyl 2-[3-(4,6-dimethoxypyrimidin-2-yl)ureidosulfonyloxy]-benzoate of melting point 148°-150° C. are obtained.

Workup

  1. additionare added at 0° C

Sources & evidence

ORD record
ord-c7e13f6fbc58471c8fdd1336e40f8b2f
Source dataset
uspto-grants-1990_10
Patent number
US04963180

Reaction notes

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