反应详情

To a solution of 2(S)-(N-morpholinocarbonyl-L-phenylalanyl-Nα -methyl-L-histidyl)amino-1-cyclohexyl-3(S)-hydroxy-6-methylheptane (1.00 g) in ethanol (10 ml) which was cooled to 0° C., was added 4N hydrogenchloride in dioxane (0.47 ml). After the mixture was stirred at the same temperature for 10 minutes, the solvent was evaporated under reduced pressure. This residue was crystallized from ethanol (1 ml) and ethyl acetate (30 ml) to give 2(S)-(N-morpholinocarbonyl-L-phenylalanyl-Nα -methyl-L-histidyl)amino-1-cyclohexyl-3(S)-hydroxy-6-methylheptane monohydrochloride (860 mg).

1. customthe solvent was evaporated under reduced pressure
2. customThis residue was crystallized from ethanol (1 ml) and ethyl acetate (30 ml)