Hydrochloric Acid → HCID 178444645, compound

HRID 1088619Notes

Reaction equation

HRID 1088619 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]([NH:9][C@H:10]([C:18]([N:20]([CH3:46])[C@H:21]([C:28]([NH:30][C@H:31]([C@@H:39]([OH:45])[CH2:40][CH2:41][CH:42]([CH3:44])[CH3:43])[CH2:32][CH:33]2[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]2)=[O:29])[CH2:22][C:23]2[N:27]=[CH:26][NH:25][CH:24]=2)=[O:19])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:8])[CH2:3][CH2:2]1.[ClH:47]>C(O)C.O1CCOCC1>[ClH:47].[O:1]1[CH2:6][CH2:5][N:4]([C:7]([NH:9][C@H:10]([C:18]([N:20]([CH3:46])[C@H:21]([C:28]([NH:30][C@H:31]([C@@H:39]([OH:45])[CH2:40][CH2:41][CH:42]([CH3:43])[CH3:44])[CH2:32][CH:33]2[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]2)=[O:29])[CH2:22][C:23]2[N:27]=[CH:26][NH:25][CH:24]=2)=[O:19])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:8])[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178444644HCID 178444644, compound

Product 1

HCID 178444645HCID 178444645, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 2(S)-(N-morpholinocarbonyl-L-phenylalanyl-Nα -methyl-L-histidyl)amino-1-cyclohexyl-3(S)-hydroxy-6-methylheptane (1.00 g) in ethanol (10 ml) which was cooled to 0° C., was added 4N hydrogenchloride in dioxane (0.47 ml). After the mixture was stirred at the same temperature for 10 minutes, the solvent was evaporated under reduced pressure. This residue was crystallized from ethanol (1 ml) and ethyl acetate (30 ml) to give 2(S)-(N-morpholinocarbonyl-L-phenylalanyl-Nα -methyl-L-histidyl)amino-1-cyclohexyl-3(S)-hydroxy-6-methylheptane monohydrochloride (860 mg).

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThis residue was crystallized from ethanol (1 ml) and ethyl acetate (30 ml)

Sources & evidence

ORD record
ord-2363c42bb13c478fa89f93348d4634f7
Source dataset
uspto-grants-1990_10
Patent number
US04963530

Reaction notes

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