Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | HCID 14836266 | HCID 14836266 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofurane dichloromethane | HCID 21919333 | — |
| Product | HCID 14836267 | HCID 14836267 | 96% |
Reaction Steps
A suspension of 5-chloro-3-[N-(2,2-dimethoxyethyl)-N-methyl(aminomethyl)]benzo[b]thiophene-2-carboxylic acid (5.0 g, 14.5 mmol) in methylene chloride-tetrahydrofuran was stirred at 0° C. and treated with excess diazomethane in ethyl ether. The mixture was stirred for 2 hours at 0° C., treated with a stream of argon and concentrated to give 5.0 g (96%) of methyl 5-chloro-3-[N-(2,2-dimethoxyethyl)-N-methyl(aminomethyl)]benzo[b]thiophene-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04963547 |
|---|
| Source dataset | uspto-grants-1990_10 |
|---|
| ORD ID | ord-57d448cfa6c64a47921121b13dce774a |
|---|
| Source note | uspto-grants-1990_10 |
|---|
