4-(4-Cyanophenyl)amino-2,6-dimethyl-3-nitropyridine → 3-Amino-4-(4-cyanophenyl)amino-2,6-dimethylpyridine

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Reaction Steps

A solution of 4-[N-(4-cyanophenyl)amino]-2,6-dimethyl-3-nitropyridine (see part (c)) (5.00 g, 18.6 mmol) in a mixture of dichloromethane (20 ml) and ethanol (100 ml) was hydrogenated at 20° C. over 10% palladium on charcoal (500 mg) at 138 kPa (20 p.s.i.) for 3 hours. The catalyst was filtered off and the solvents were removed under reduced pressure to give the title compound as a brown solid, (4.20 g, 94%).

Provenance & Evidence