Nitric Acid → HCID 15636997, compound

Participants

Reaction Conditions

Reaction Steps

1,3-Dihydro-5-methyl-6-phenyl-2H-imidazo[4,5-b]pyridin-2-one (Example 4c, 8.06 g) was added in small portions to 80 ml 90% nitric acid cooled to -2° C. The reaction mixture was stirred at 0° C. for 2 hours and then poured portion wise into ice-water. The solid product was collected, washed with water and ether, and dried in high vacuum at 110-130° C. to give 9.3 g (97%) of 1,3-dihydro-5-methyl-6-(4-nitrophenyl)-2H-imidazo[4,5-b]pyridin-2-one, m.p. above 300° C. Further purification was accomplished by repeated recrystallization from aqueous dimethylformamide.

Provenance & Evidence