Acetic Anhydride → HCID 14822881, compound

HRID 1088676Notes

Reaction equation

HRID 1088676 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[NH:18][C:17](=[O:19])[NH:16][C:12]3=[N:13][C:14]=2[CH3:15])=[CH:5][CH:4]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>>[C:20]([NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[NH:18][C:17](=[O:19])[NH:16][C:12]3=[N:13][C:14]=2[CH3:15])=[CH:5][CH:4]=1)(=[O:22])[CH3:21]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 20060128HCID 20060128, compound

Product 1

HCID 14822881HCID 14822881, compoundYield 90%

Procedure

[I; Ar 4-CH3CONHC6H4, R1 and R3 =H, R5 =CH3 ]was prepared from 1.73 g 6-(4-aminophenyl)-1,3-dihydro-5-methyl-2H-imidazo[4,5-b]pyridin-2-one hydrochloride and 0.65 ml acetic anhydride according to the procedure of Example 7, and was obtained in 90% yield as a colorless solid, m.p. above 300° C. when recrystallized from aqueous DMF.

Workup

  1. customwas obtained in 90% yield as a colorless solid, m.p. above 300° C. when
  2. customrecrystallized from aqueous DMF

Sources & evidence

ORD record
ord-ca6ff36990754a4293b1a152a78d1639
Source dataset
uspto-grants-1990_10
Patent number
US04963561

Reaction notes

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