1-Butanesulfonyl chloride → HCID 14822882, compound

HRID 1088677Notes

Reaction equation

HRID 1088677 reaction equation
CC1N=C2NC(=O)NC2=CC=1.Cl.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[C:22]3[NH:29][C:28](=[O:30])[NH:27][C:23]3=[N:24][C:25]=2[CH3:26])=[CH:16][CH:15]=1.[CH2:31]([S:35](Cl)(=[O:37])=[O:36])CCC>>[CH3:31][S:35]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:21]=[C:22]3[NH:29][C:28](=[O:30])[NH:27][C:23]3=[N:24][C:25]=2[CH3:26])=[CH:16][CH:15]=1)(=[O:37])=[O:36]

Participants

4

Reactant 3

HCID 754301-Butanesulfonyl chlorideHCID 127065511,3-Dihydro-5-methyl-2H-imidazo[4,5-b]pyridin-2-oneHCID 20060128HCID 20060128, compound

Product 1

HCID 14822882HCID 14822882, compound

Procedure

Example 10 6-4-(Butanesulfonylamino)phenyl]-1,3-dihydro-5-methyl2H-imidazo[4,5-b]pyridin-2-one [I; Ar =4-CH3 (CH2)3SO2NHC6H4, R1 and R3 =H, R5 =CH3 ]was prepared from 1.5 g 6-(4-aminophenyl)-1,3-dihydro-5-methyl-2H-imidazo[4,5-b]pyridin-2-one hydrochloride and 0.91 ml butanesulfonyl chloride according to the procedure of Example 7, and was obtained (0.92 g) as a colorless solid, m.p. above 300° C. when recrystallized from ethanol.

Workup

  1. customwas obtained (0.92 g) as a colorless solid, m.p. above 300° C. when
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-d0aa438baa6c42a9921ad6929467c6d0
Source dataset
uspto-grants-1990_10
Patent number
US04963561

Reaction notes

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