Nitric Acid → HCID 20060121, compound

Participants

Reaction Steps

It is further contemplated that 1,3-dihydro-6(4-hydroxyphenyl)-5-methyl-2H-imidazo[4,5-b]pyridin-2-one (Example 16) can be nitrated with nitric acid to obtain 6-(4-hydroxy-3-nitrophenyl)-1,3-dihydro-5-methyl-2H-imidazo[4,5-b]pyridin-2-one [I; Ar 3-O2N-4-HOC6H3, R1 and R3 =H, R5 =CH3 ], which in turn can be reduced by catalytic hydrogenation to obtain 6-(3-amino-4-hydroxyphenyl)-1,3-dihydro-5-methyl-2H-imidazo[4,5-b]pyridin-2-one I; Ar =3-H2N-4-HOC6H3, R1 and R3 =H, R5 =CH3 ].

Provenance & Evidence