Boron trifluoride etherate → 2-Propylvaleraldehyde

To a vigorously stirred solution of 2 propyl 1,2 epoxypentane (1 equivalent), prepared as described in Example 1, in benzene cooled to 0° was added a solution of boron trifluoride etherate (0.5 equivalents) in benzene. The reaction mixture was stirred for 1 min and was quenched by the addition of water. Following separation of the phases, the organic phase was washed with saturated aqueous sodium bicarbonate and water, dried with magnesium sulfate, filtered and concentrated to give a colorless oil. The oil was distilled to give the desired product as a colorless oil; 75% yield; boiling point (b.p) 60-63° /0.1 mm.

1. temperaturecooled to 0°
2. customwas quenched by the addition of water
3. customseparation of the phases
4. washthe organic phase was washed with saturated aqueous sodium bicarbonate and water
5. dry with materialdried with magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customto give a colorless oil
9. distillationThe oil was distilled

ORD record

ord-e701230815734e8bbd2f5de03c3d39bd

Source dataset

uspto-grants-1990_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04963557