Hydrochloric Acid → HCID 131716664, compound

Participants

Reaction Steps

A 1.7 g amount of 1,2-dihydro-1-[[4-(phenylmethyl)-1-piperazinyl]acetyl]-4-[3-(trifluoromethyl)phenyl]imidazo[1,5-a]pyrimidine-8-carbonitrile (Example 7) was dissolved in 50 ml of ethyl alcohol with heating. The solution was cooled and acidified with 7.0 ml of 2.94N alcoholic hydrochloric acid. Then an excess of ether was added. The precipitate was collected, washed with ether and dried. The solid was dissolved by heating in 75 ml of ethanol. The solution was filtered, then the filtrate was chilled to recrystallize 1.0 g of the desired product as white crystals, mp 225°-227° C.

Provenance & Evidence