p-Toluenesulfonic acid monohydrate → HCID 21982260, compound

Participants

Reaction Steps

Ethyl 2-(4-nitro-1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-3-oxo-butyrate was prepared (116 mg, 22%) in the same manner as described in the above example 6 (20) from ethyl 3-(4-nitro-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(2-methyl-[1,3]dioxolan-2-yl)propionate (0.38 g, 1.58 mmol) and p-toluenesulfonic acid monohydrate (25 mg), and the obtained product was identified with the following NMR data.

Provenance & Evidence