反应详情

2-Pyridinehexanol (4.88 g), 1,6-dibromohexane (12.6 ml), 12.5M aqueous sodium hydroxide (25 ml) and TAB (0.45 g) were stirred rapidly at room temperature for 7 h. The mixture was diluted with water (60 ml) and extracted with diethyl ether (3×60 ml). The combined organic extracts were washed with water (60 ml) and brine (60 ml), dried and concentrated to give an oil which was purified by FCC eluting with diethyl ether-hexane (0:1→1:1) to give the title compound as a colourless oil (4.52 g), t.l.c. (ether-hexane 1:1) Rf 0.25.

1. extractionextracted with diethyl ether (3×60 ml)
2. washThe combined organic extracts were washed with water (60 ml) and brine (60 ml)
3. customdried
4. concentrationconcentrated
5. customto give an oil which
6. customwas purified by FCC
7. washeluting with diethyl ether-hexane (0:1→1:1)