1,6-Dibromohexane → HCID 22161743, compound

Participants

Reaction Steps

A mixture of 3-pyridinepropanol (10 g), 1,6-dibromohexane (40 ml) 50% (w/v) sodium hydroxide (40 ml) and TAB (1.0 g) was stirred at room temperature for 3 h, water (150 ml) was added and the mixture was extracted with ether (2×200 ml). The organic extracts were washed with water and brine, dried and concentrated to an oil which was purified by FCC eluting with hexane→hexane-ether (1:1), to give the title compound as a yellow oil (11.0 g), t.l.c. (hexane-ether 1:1) Rf 0.16.

Provenance & Evidence