反应详情

2-[3-[(6-Bromohexyl)oxy]propyl]pyridine (17.0 g) was added to benzylamine (50 ml) at 140° under nitrogen. After 1 h at 140° the reaction mixture was cooled and partitioned between 2N sodium hydroxide (250 ml) and ether (250 ml). The organic layer was washed with water and brine, dried and concentrated to a yellow oil. The excess benzylamine was removed by distillation to give the title compound as a yellow oil (18.5 g), t.l.c. (System A 80:20:2) Rf 0.42.

1. temperatureAfter 1 h at 140° the reaction mixture was cooled
2. custompartitioned between 2N sodium hydroxide (250 ml) and ether (250 ml)
3. washThe organic layer was washed with water and brine
4. customdried
5. concentrationconcentrated to a yellow oil
6. customThe excess benzylamine was removed by distillation