2-Bromo-1-(4-hydroxy-3-(hydroxymethyl)phenyl)ethan-1-one → 1-[4-Hydroxy-3-(hydroxymethyl)phenyl]-2-[(phenylmethyl)[6-[[6-(2-pyridinyl)hexyl]oxy]hexyl]amino]ethanone

Participants

Reaction Steps

A solution of 2-bromo-1-[4-hydroxy-3-(hydroxymethyl)phenyl]ethanone (1.00 g), N-[6-[[6-(2-pyridinyl)hexy]oxy]hexyl]benzenemethanamine (1.5 g) and DEA (1.58 g) in THF (20 ml) was left to stand for 24 h. The reaction mixture was filtered and the filtrate was concentrated to give an oil which was purified by FCC eluting with System B (95:5:1), to give the title compound as a yellow oil (1.96 g), t.l.c. (System A 80:20:2)) Rf 0.33.

Provenance & Evidence