反应详情

A solution of 2-[6-[(6-bromohexyl)oxy]-1-hexynyl]quinoline (2.29 g) in ethanol (120 ml) was hydrogenated at room temperature and pressure over pre-reduced 10% palladium on carbon (1 g) for 20 min. The catalyst was removed by filtration through hyflo and the filtrate evaporated in vacuo to a brown oil. Purification by FCC eluting with hexane-ether (2:1) gave the title compound as a pale brown oil (1.70 g), t.l.c. (hexane:ether 2:1) Rf 0.21.

1. customwas hydrogenated at room temperature
2. customThe catalyst was removed by filtration through hyflo
3. customthe filtrate evaporated in vacuo to a brown oil
4. customPurification by FCC
5. washeluting with hexane-ether (2:1)