反应详情

A mixture of 3-(phenylmethoxy)-2-pyridinepropanol (1.4 g), 1,6-dibromohexane (4 ml), 40% aqueous sodium hydroxide (4 ml) and TAB (100 mg) was stirred vigorously for 6 days. Water (10 ml) was added and the mixture was extracted with ether (3×10 ml). The ether extracts were washed with water and brine, dried and concentrated to an oil which was purified by FCC eluting with cyclohexane followed by cyclohexane/ethyl acetate (4:1) to give the title compound as an orange oil (1.0 g) t.l.c. (cyclohexane/ethyl acetate 4:1) Rf 0.25.

1. extractionthe mixture was extracted with ether (3×10 ml)
2. washThe ether extracts were washed with water and brine
3. customdried
4. concentrationconcentrated to an oil which
5. customwas purified by FCC
6. washeluting with cyclohexane