N-[5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl]methanesulphonamide → HCID 131716665, compound

Participants

Reaction Steps

A mixture of 2-[4-[(6-bromohexyl)oxy]butyl]quinoline (900 mg), N-[5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl]methanesulphonamide (800 mg) and DEA (0.52 ml) in DMF (50 ml) was heated at 100° for 4 h, cooled, and the solvent evaporated in vacuo. The residue was purified by FCC eluting with System A (39:10:1) and (34:15:1). A solution of the resulting product in methanol (10 ml) was treated with benzoic acid (61.3 mg), the solution evaporated in vacuo and triturated with dry ether (×2) to afford the title compound as a fawn powder (250 mg) m.p. 155°-157°.

Provenance & Evidence