Sodium Carbonate → HCID 131716669, compound

HRID 1088760Notes

Reaction equation

HRID 1088760 reaction equation
[Cl:1][CH2:2][C:3]([N:5]1[CH2:10][C:9]([CH3:11])=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[N:7]2[N:19]=[CH:20][C:21]([C:22]#[N:23])=[C:6]12)=[O:4].C(=O)([O-])[O-].[Na+].[Na+].[CH2:30]([N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:55].Cl>C1(C)C=CC=CC=1>[ClH:1].[ClH:55].[Cl:18][C:14]1[CH:13]=[C:12]([C:8]2[N:7]3[N:19]=[CH:20][C:21]([C:22]#[N:23])=[C:6]3[N:5]([C:3](=[O:4])[CH2:2][N:40]3[CH2:41][CH2:42][N:37]([CH2:30][C:31]4[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH2:38][CH2:39]3)[CH2:10][C:9]=2[CH3:11])[CH:17]=[CH:16][CH:15]=1

Participants

6

Reactant 4

HCID 10340Sodium CarbonateHCID 759941-BenzylpiperazineHCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 15101087HCID 15101087, compound

Product 1

HCID 131716669HCID 131716669, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 3.1 g of 4-(chloroacetyl)-7-(3-chlorophenyl)-4,5-dihydro-6-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile, 1.1 g of sodium carbonate, 1.7 g of N-benzylpiperazine and 115 ml of toluene was reacted as described in Example 16, giving the base form of the product which was converted to the dihydrochloride salt by the procedure of Example 97, giving 1.3 g, mp 201°-203° C.

Workup

  1. customwas reacted
  2. customgiving the base form of the product which
  3. customgiving 1.3 g, mp 201°-203° C.

Sources & evidence

ORD record
ord-e46f7252583646239e5ab57809b1acbc
Source dataset
uspto-grants-1990_10
Patent number
US04963553

Reaction notes

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