HCID 54154381, compound → HCID 19756206, compound

HRID 1088772Notes

Reaction equation

HRID 1088772 reaction equation
C[N:2]([CH3:19])[CH:3]=[C:4]([CH2:17][CH3:18])[C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:16])([F:15])[F:14])[CH:8]=1)=O.N[C:21]1[C:25]([C:26]#[N:27])=C[NH:23][N:22]=1>C(O)(=O)C>[CH2:17]([C:4]1[CH:3]=[N:2][C:19]2[N:23]([N:22]=[CH:21][C:25]=2[C:26]#[N:27])[C:5]=1[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13]([F:14])([F:15])[F:16])[CH:8]=1)[CH3:18]

Participants

4

Reactant 2

HCID 54154381HCID 54154381, compoundHCID 178510443HCID 178510443, compound

Product 1

HCID 19756206HCID 19756206, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 4.0 g of 3-dimethylamino-2-ethyl-3'-trifluoromethylacrylophenone and 1.5 g of 3-amino-4-cyanopyrazole in 75 ml of glacial acetic acid was refluxed for two hours to give 6-ethyl-7-[3-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, m.p. 135°-137° C.

Workup

  1. temperaturewas refluxed for two hours

Sources & evidence

ORD record
ord-cfb0d275d7d0444e935a614c37eb4ce5
Source dataset
uspto-grants-1990_10
Patent number
US04963553

Reaction notes

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