Sodium Carbonate → HCID 15101025, compound

HRID 1088775Notes

Reaction equation

HRID 1088775 reaction equation
Cl[CH2:2][C:3]([N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:7]2[N:17]=[CH:18][C:19]([C:20]#[N:21])=[C:6]12)=[O:4].[CH3:22][O:23][C:24]1[CH:25]=[C:26]([CH:34]=[CH:35][CH:36]=1)[CH2:27][N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1.C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1>[CH3:22][O:23][C:24]1[CH:25]=[C:26]([CH2:27][N:28]2[CH2:33][CH2:32][N:31]([CH2:2][C:3]([N:5]3[CH2:10][CH:9]=[C:8]([C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=4)[N:7]4[N:17]=[CH:18][C:19]([C:20]#[N:21])=[C:6]34)=[O:4])[CH2:30][CH2:29]2)[CH:34]=[CH:35][CH:36]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 4282851-(3-methoxybenzyl)piperazineHCID 19756218HCID 19756218, compound

Product 1

HCID 15101025HCID 15101025, compoundYield 25.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 3.8 g of 4-(chloroacetyl)-4,5-dihydro-7-phenylpyrazolo[1,5-a]pyrimidine-3-carbonitrile, 2.9 g of 3-methoxybenzyl piperazine and 1.6 g of sodium carbonate in 165 ml of toluene was reacted as described in Example 146. The product was recrystallized from isopropanol, giving 1.5 g of the desired product, mp 98°-100° C.

Workup

  1. customwas reacted
  2. customThe product was recrystallized from isopropanol

Sources & evidence

ORD record
ord-4c63d1bf77b746b7934610e23c4093a5
Source dataset
uspto-grants-1990_10
Patent number
US04963553

Reaction notes

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