HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1088786Generated: October 31, 2026
Thionyl Chloride → 1-Methyl-8-chloromethyl-1,2,3,4-tetrahydroquinoline
https://huagongshe.com/reaction/1088786
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (1-Methyl-1,2,3,4-tetrahydroquinolin-8-yl)methanol | HCID 15053143 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Methyl-8-chloromethyl-1,2,3,4-tetrahydroquinoline | HCID 15053142 | — |
Reaction Steps
1-Methyl-8-hydroxymethyl-1,2,3,4-tetrahydroquinoline (0.89 g) was dissolved in dichloromethane (30 ml), and thionyl chloride (1.09 ml) was added thereto, and the mixture was stirred for 2 hours at 45° C. After distilling off the solvent, n-hexane was added to the residue, and the solvent was distilled off under reduced pressure to give 1-methyl-8-chloromethyl-1,2,3,4-tetrahydroquinoline (1.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04963566 |
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| Source dataset | uspto-grants-1990_10 |
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| ORD ID | ord-9b4e89eb7660459282e501acd1261d69 |
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| Source note | uspto-grants-1990_10 |
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