反应详情

8-Hydroxymethylquinoline (1.0 g) was dissolved in methanol (30 ml). Platinum oxide (0.25 g) was added thereto and the mixture was subjected to catalytic reduction at 3.5 kg/cm2, 40° C. After completion of the catalytic reduction, the catalyst was filtered off and the filtrate was concentrated under reduced pressure. The resulting residue was recrystallized from ethyl acetate-n-hexane to give 8-hydroxymethyl-1,2,3,4-tetrahydroquinoline (1.0 g). Yellow needle crystals mp: 67°-68° C.

1. customwas subjected to catalytic reduction at 3.5 kg/cm2, 40° C
2. filtrationAfter completion of the catalytic reduction, the catalyst was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe resulting residue was recrystallized from ethyl acetate-n-hexane