Hydroxyamine hydrochloride → HCID 73867443, compound

Participants

Reaction Steps

6,7-Dihydro-3,7-dioxo-1H,3H,5H-pyrido[3,2,1-ij][3,1]benzoxazine (5 g), hydroxylamine hydrochloride (2.1 g) and sodium acetate (7.5 g) were dissolved in a mixed solvent of ethanol-water (5:1) (90 ml) and the mixture was refluxed for 2 hours. After completion of the reaction, the solvent was distilled off and the resulting residue was poured into water. Crystals which precipitated were collected by filtration and dried to give 6,7-dihydro-3-oxo-7-hydroxyimino-1H,3H,5H-pyrido[3,2,1-ij][3,1]benzoxazine. The compound was dissolved in acetic acid (150 ml) and platinum oxide (250 mg) was added thereto. The mixture was subjected to catalytic reduction at 50° C. and 4 atmospheres. After completion of the catalytic reduction, catalyst was filtered off and the filtrate was concentrated to give 6,7-dihydro-3-oxo-7-amino-1H,3H,5H-pyrido [3,2,1-ij][3,1]benzoxazine (5 g).

Provenance & Evidence