Sodium Hydroxide → HCID 14685752, compound

Participants

Reaction Steps

To a solution of 6,7-dihydro-3-oxo-7-(N-methyl-N-allylamino)-1H,3H,5H-pyrido[3,2,1-ij][3,1]benzoxazine (5.89 g) in methanol (80 ml) was added 15% aqueous solution of sodium hydroxide (20 ml) and the mixture was refluxed for 6 hours. After distilling off methanol and extracting with dichloromethane, the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off to give 4-(N-methyl-N-allylamino)-8-hydroxymethyl-1,2,3,4-tetrahydroquinoline (4.83 g).

Provenance & Evidence