Acetic Anhydride → HCID 22161803, compound

Participants

Reaction Steps

To a solution of 8-(t-butyldimethylsilyloxymethyl)-4-hydroxymethyl-1-ethyl-1,2,3,4-tetrahydroquinoline (1.98 g) in pyridine (5 ml), acetic anhydride was added dropwise with stirring under ice-cooling and the mixture was stirred for 2 hours at room temperature. Pyridine was distilled off under reduced pressure, and the resultant residue was extracted with dichloromethane. After washing with a saturated aqueous solution of copper sulfate and with water in this order, the mixture was dried and the solvent was distilled off under reduced pressure to give 8-t-butyldimethylsilyloxymethyl-4-acetyloxymethyl-1-ethyl-1,2,3,4-tetrahydroquinoline (2.23 g).

Provenance & Evidence