反应详情

(1-Methyl-1,2,3,4-tetrahydroquinolin-8-yl)methyl lithium (18.3 g) was dissolved in benzene (150 ml). After adding (5-methoxy-2-benzimidazolyl)sulfinyl chloride (20.1 g) thereto, the mixture was refluxed for 2 hours. The resulting lithium chloride was filtered off, and the filtrate was concentrated under reduced pressure. The resulting residue was recrystallized from ethyl acetate to give 8-(5-methoxy-2-benzimidazolyl)sulfinylmethyl-1-methyl-1,2,3,4-tetrahydroquinoline (1.1 g).

1. temperaturethe mixture was refluxed for 2 hours
2. filtrationThe resulting lithium chloride was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe resulting residue was recrystallized from ethyl acetate