Methyl iodide → HCID 15053211, compound

Participants

Reaction Steps

8-(2-Benzimidazolyl)sulfinylmethyl-1,2,3,4-tetrahydroquinoline (14.9 g) was dissolved in dimethyl formamide (150 ml). Sodium hydride (60% in oil, 2.2 g) was added thereto with stirring under ice-cooling, and the mixture was stirred for 30 minutes. Sequentially, methyl iodide (8.5 g) was added dropwise to the reaction mixture and the mixture was stirred for 5 hours at 70° to 80° C. After distilling off the solvent, the residue was poured into water and the mixture was extracted with chloroform. The residue obtained by distilling off the chloroform was purified by silica gel column chromatography and recrystallized from diethyl ether-n-hexane to give 1-methyl-8-(2-benzimidazolyl)sulfinylmethyl-1,2,3,4-tetrahydroquinoline (2.1 g).

Provenance & Evidence