Sodium borohydride → HCID 15053185, compound

Participants

Reaction Steps

To a solution of 8-(2-benzimidazolyl)thiomethyl-1-methyl-4-oxo-1,2,3,4-tetrahydroquinoline (300 mg) in methanol (10 ml) was added gradually sodium borohydride (35 mg) at 0° C. The reaction mixture was stirred for 40 minutes at room temperature. After distilling off the solvent, the resulting residue was extracted with dichloromethane, washed with water, and dried. Then the solvent was distilled off and the resulting residue was recrystallized from ethyl acetate-n-hexane to give 8-(2-benzimidazolyl)thiomethyl-1-methyl-4-hydroxy-1,2,3,4-tetrahydroquinoline (238 mg).

Provenance & Evidence