Sodium Hydroxide → HCID 15053285, compound

Participants

Reaction Steps

To a solution of 8-(2-benzimidazolyl)sulfinylmethyl-1-ethyl-3-ethoxycarbonyl-1,2,3,4-tetrahydroquinoline(0.4 g) in methanol (80 ml) was added sodium hydroxide (0.2 g) and the mixture was stirred for 2 hours at room temperature and furthermore refluxed for 3 hours. The solvent was distilled off under reduced pressure The resulting residue was dissolved in water, and the solution was adjusted to acidic with acetic acid. The precipitate was collected by filtration and recrystallized from methanol to give 8-(2-benzimidazolyl)sulfinylmethyl-1-ethyl-1,2,3,4-tetrahydroquinoline-3-carboxylic acid.1/2 hydrate (0.2 g).

Provenance & Evidence