Nitric Acid → 1-(4-Hydroxy-3-methoxy-5-nitrophenyl)ethanone

Participants

Reaction Conditions

Reaction Steps

To a solution containing 40 ml of nitric acid (d=1.41) and 40 ml of water was gradually added while cooling (below 7° C.) and stirring 25.0 g of 4'-hydroxy-3'-methoxyacetophenone. After stirring for 0.5 h at 0° C. the product was filtered, washed first with diluted nitric acid (1:1) and then with water. Yield 24.0 g (75%). The 1H-NMR-spectrum of the product was in accordance with the structure alleged.

Provenance & Evidence