反应详情

To a solution containing 10.0 g of dimethoxy-5-chlorobenzaldehyde and 8.3 ml of ethyl crotonate in 65 ml of N-methylpyrrolidone 6.7 g of potassium tert.-butoxide was added with stirring. The solution was stirred for 0.5 h more at 20° C. and the solution was poured then to a mixture of ice and hydrochloric acid and extracted with ether. The ether extract was washed with water and extracted then with NaHCO3 -solution. The aqueous phase was acidified with hydrochloric acid and the semisolid product was separated and washed with water. Yield 7.3 g (55%).

1. additionwas added
2. stirringThe solution was stirred for 0.5 h more at 20° C.
3. additionthe solution was poured
4. extractionextracted with ether
5. extractionThe ether extract
6. washwas washed with water
7. extractionextracted
8. customthe semisolid product was separated
9. washwashed with water