Boron tribromide dichloromethane → HCID 54439514, 화합물

HRID 1088858노트

반응식

HRID 1088858 반응식
C[O:2][C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=[CH:15][C:16]([OH:18])=[O:17])[C:6]([Cl:11])=[CH:7][C:8]=1[O:9]C.B(Br)(Br)Br.ClCCl>ClCCl>[OH:2][C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=[CH:15][C:16]([OH:18])=[O:17])[C:6]([Cl:11])=[CH:7][C:8]=1[OH:9]

참가 물질

4

반응물 2

HCID 22277759Boron tribromide dichloromethaneHCID 540567045-(3,4-Dimethoxy-6-chlorophenyl)-2,4-pentadienoic acid

생성물 1

HCID 54439514HCID 54439514, 화합물수율 46%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
20 °C

실험 절차

To a solution containing 0.54 g of the product obtained in Example 35 in 6 ml dichloromethane 6 ml of 1 molar boron tribromide-dichloromethane solution was added and stirred for 24 h at 20° C. The solvent was evaporated in vacuo and 2 N hydrochloric acid was added to the residue. The product was filtered and washed with water. Recrystallization from isopropanol-water yielded 0.22 g (46%) of the product desired, m.p. 203°-206° C.

후처리

  1. additionwas added
  2. customThe solvent was evaporated in vacuo and 2 N hydrochloric acid
  3. additionwas added to the residue
  4. filtrationThe product was filtered
  5. washwashed with water
  6. customRecrystallization from isopropanol-water

출처 및 근거

ORD 기록
ord-224e25ea95e34c658891732538aa270e
출처 데이터셋
uspto-grants-1990_10
특허 번호
US04963590

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