反应详情

At 0° C., 1.2 equivalents of palmitoyl chloride were added to a solution of 3'-deoxy-3'-fluorothymidine in pyridine. The solution was warmed slowly to room temperature. As soon as a thin layer chromatographic control (CHCl3 /methanol=95/5 on silica gel) showed a complete reaction, the solution was poured into ice water. The aqueous phase was decanted, the resulting oil was chromatographed on silica gel with chloroform eluent. The title compound was recovered from the suitable fractions by evaporation of the solvent. M.P. 65°-66° C. (cyclohexane).

1. customa complete reaction
2. customThe aqueous phase was decanted
3. customthe resulting oil was chromatographed on silica gel with chloroform eluent
4. customThe title compound was recovered from the suitable fractions by evaporation of the solvent