2,2-Diethoxyethylamine → HCID 13911324, compound

Participants

Reaction Steps

Platinum oxide was added in an amount of 1.0 g to 100 ml of ethanol, and hydrogen gas was passed through the mixture with stirring for 30 minutes. Then, 54.06 g (0.3 mol) of 2-methoxy-3,4-methylenedioxybenzaldehyde (1) and 40.78 g (0.3 mol) of aminoacetaldehyde diethylacetal (98% purity) in 100 ml of ethanol were added and hydrogenation was carried out while stirring the reaction mixture at room temperature for 8.5 hours. The catalyst was then removed by filtration and the solvent was distilled off at reduced pressure to obtain 89.43 g of N-(2-methoxy-3,4-methylenedioxybenzyl)aminoacetaldehyde diethylacetal (2) as an oil with 100% yield. IR and NMR of the resultant product are listed below.

Provenance & Evidence