反应详情

温度

60 °C

8-Methoxy-6,7-methylenedioxyisoquinoline (5) in an amount of 2.03 g (10 mmol) was dissolved into 40 ml of toluene while heating them at 60° C. Then, 1.13 ml (12 mmol) of dimethyl sulfate was added and stirred at 60° C. for 4 hours. After cooling, deposited crystals were collected by filtration, washed with toluene and then dried to obtain 3.30 g of 8-methoxy-2-methyl-6,7-methylenedioxyisoquinolinium methyl sulfate (6) with a yield of 100%. The resultant product was then recrystallized from ethanol: m.p. 172°-4° C. IR and NMR of the resultant product are listed below.

1. temperatureAfter cooling
2. filtrationdeposited crystals were collected by filtration
3. washwashed with toluene
4. customdried