HCID 13671488, compound → HCID 22162210, compound

HRID 1088939Notes

Reaction equation

HRID 1088939 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([CH3:28])[C:14]2[C:9](=[CH:10][C:11]([NH:18][C:19]([C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)=[O:20])=[C:12]([N+:15]([O-])=O)[CH:13]=2)[NH:8][C:7]1=[O:27])=[O:5])[CH3:2]>[Pd].CO>[NH2:15][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][C:11]=1[NH:18][C:19]([C:21]1[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=1)=[O:20])[NH:8][C:7](=[O:27])[C:6]2([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH3:28]

Participants

4

Reactant 1

HCID 13671488HCID 13671488, compound

Product 1

HCID 22162210HCID 22162210, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 12.4 g. (32.2 mmol) 3-ethoxycarbonyl-3-methyl-5-nitro-6-(4-pyridinoylamino)-indolin -2-one in 500 ml. methanol is hydrogenated at ambient temperature in the presence of 1 g. 10% Pd/C. The catalyst is filtered off with suction, the filtrate is evaporated and the substance obtained is immediately further worked up.

Workup

  1. customis hydrogenated at ambient temperature in the presence of 1 g
  2. filtrationThe catalyst is filtered off with suction
  3. customthe filtrate is evaporated
  4. customthe substance obtained

Sources & evidence

ORD record
ord-4d4e6c6384924a6f85da4f71d43c967f
Source dataset
uspto-grants-1990_10
Patent number
US04963686

Reaction notes

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