HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 22162232, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Isobutyraldehyde | HCID 6561 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-(2-Oxoindolin-6-yl)acetamide | HCID 2749839 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 22162232 | HCID 22162232 | — |
Reaction Steps
A solution of 1.9 g. sodium hydroxide in 2 ml. water is added dropwise to a suspension of 9 g. (0.047 mol) 6-acetamidoindolin-2-one in 50 ml. ethanol containing 3.4 g. (0.047 mol) isobutyraldehyde. After about 5 hours, the reaction mixture is evaporated to dryness and the residue is purified on silica gel (elution agent: methylene chloride/ammonia-saturated methanol). Yield: 7.6 g. (65% of theory) of foam; m.p. 93° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04963686 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-7b0e4240c54a41ae98ec79b0be0f6393 |
| Source note | uspto-grants-1990_10 |