HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 22162235, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Isonicotinoyl chloride hydrochloride | HCID 12262826 | — |
| Reactant | 5-amino-3,3-dimethylindolin-2-one | HCID 22162091 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 22162235 | HCID 22162235 | — |
Reaction Steps
A suspension of 5.0 g. (0.028 mol) 5-amino-3,3-dimethylindolin-2-one in 100 ml. methylene chloride containing 14 ml. triethylamine is mixed, while cooling, with 7.0 g. (0.04 mol) isonicotinic acid chloride hydrochloride. Subsequently, the reaction mixture is evaporated and the residue is digested with water, filtered with suction and recrystallised from ethanol. Yield: 5.8 g. (73% of theory); m.p.>300° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04963686 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-b194073b75ac4c95bee4a8394a4b5e0c |
| Source note | uspto-grants-1990_10 |