反应详情

A suspension of 0.65 g (1.4 mmol) of [1R,8S,9aR]-1-carbobenzyloxyamino-5,6-dimethoxy-2,3,7,8,9,9a-hexahydro-8-phenyl-phenalene, from Step 6, in 50 mL of methanol and 0.1 g of 10% palladium on carbon was stirred under 1 atmosphere of hydrogen for 1 hour. The solid dissolved as the reaction proceeded. The palladium catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give 0.4 g (87% yield) of crude product which was carried on to the next step without further purification.

1. dissolutionThe solid dissolved as the reaction
2. customThe palladium catalyst was removed by filtration
3. concentrationthe filtrate was concentrated under reduced pressure