反应详情

温度

70 °C

3,5,6-Trichloro-2-pyridyloxyacetic acid (20 g, 0.078 mole was stirred with toluene (46.5 ml). Thionyl chloride (26 ml) was added dropwise to the well-stirred mixture over 15 minutes. The mixture was then heated under reflux (70° C.) for 3 hours. The effluent gases (SO2 +HCl) were absorbed into aqueous 5N sodium hydroxide. The cooled reaction mixture was filtered and evaporated to yield the title compound (20.9 g, 98 percent) as a thick dark brown oil.

1. temperatureThe mixture was then heated
2. customThe effluent gases (SO2 +HCl) were absorbed into aqueous 5N sodium hydroxide
3. customThe cooled reaction mixture
4. filtrationwas filtered
5. customevaporated