HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 14075268, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl 3-(4-Fluorophenyl)-3-Oxopropanoate | HCID 2758844 | — |
| Solvent | Phosphorus Pentoxide-Methanesulfonic Acid | HCID 86584057 | — |
| Product | HCID 14075268 | HCID 14075268 | — |
Reaction Steps
25 gms of ethyl 4-fluorobenzoylacetate was dissolved in 250 gms of 1:10 P2O5 /methanesulfonic acid and heated at 45° for 4 days. The mixture was cooled, poured into 1200 mls of water and extracted with (3×100 mls) methylene chloride. Evaporation of the solvent and chromatography of the resulting oil (silica gel/ether) provided 12.9 gms of crystalline 2,6-di(4'-fluorophenyl)-3-ethoxycarbonyl-pyr-4-one. mp=113-114.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04964896 |
| Source dataset | uspto-grants-1990_10 |
| ORD ID | ord-07cd76276d304c4fbb5a322d70fa175d |
| Source note | uspto-grants-1990_10 |