1-(4-Iodophenyl)-4-propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octane → 4-n-Propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octane

HRID 1089144Notes

Reaction equation

HRID 1089144 reaction equation
IC1C=CC([C:8]23[O:15][CH2:14][C:11]([CH2:16][CH2:17][CH3:18])([CH2:12][O:13]2)[CH:10]([C:19]([F:22])([F:21])[F:20])[O:9]3)=CC=1.C(C12COC(C3C=CC(C#CCOC)=CC=3)(OC1)OC2)(C)(C)C>>[CH2:16]([C:11]12[CH2:14][O:15][CH:8]([O:13][CH2:12]1)[O:9][CH:10]2[C:19]([F:20])([F:21])[F:22])[CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 150219591-(4-Iodophenyl)-4-propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octaneHCID 150219664-t-Butyl-1-[4-(3-methoxyprop-1-ynyl)phenyl]-2,6,7-trioxabicyclo[2,2,2]octane

Product 1

HCID 867443044-n-Propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octane

Procedure

1-[4-(3-Methoxyprop-1-ynl)phenyl[-4-n-propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octane was prepared from 1-(4-iodophenyl)-4-n-propyl-3-trifluoromethyl-2,6,7-trioxabicyclo[2,2,2]octane and methyl propargyl ether using the methodology described in Example 3.

Sources & evidence

ORD record
ord-41331ad50e854801a41f942c33300987
Source dataset
uspto-grants-1990_10
Patent number
US04965257

Reaction notes

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