Triphenylphosphine → (3-Carboxypropyl)(triphenyl)phosphanium bromide

Participants

Reaction Conditions

Reaction Steps

A mixture of 100 g of 4-bromobutyric acid and 156.9 g of triphenylphosphine was heated under argon at 130° C. for 2 hours. The cooled reaction mixture was suspended in 250 mL of chloroform and heated to reflux, then diluted with 200 mL of ether. This was stirred for 30 minutes at room temperature, chilled to 0° C, and filtered. The solid was dried in vacuo to afford 240 g title salt.

Provenance & Evidence